Zio’s Twelve 21 Pizzeria & Restaurant Menu With Prices

Name: Zio’s Twelve 21 Pizzeria & Restaurant
Address: 1221 S Sumter Blvd, North Port, FL 34287, North Port, FL, US
Telephone: (941) 426-9800
Price range: $

Contact & Location

pizza restaurant · $

1221 S Sumter Blvd, North Port, FL 34287

(941) 426-9800 · tap to call

ziosofnorthport.com

How far is Zio’s Twelve 21 Pizzeria & Restaurant?

1221 S Sumter Blvd, North Port, FL 34287

Distance from central North Port2.0 mi

Straight-line distance from the midpoint of our North Port listings.

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Hours of Operation

MondayClosed

Tuesday11:30 AM–8:30 PM

Wednesday11:30 AM–8:30 PM

Thursday11:30 AM–8:30 PM

Friday11:30 AM–8:30 PM

Saturday11:30 AM–8:30 PM

Sunday3–8:30 PM

See It Before You Go

Short videos of Zio’s Twelve 21 Pizzeria & Restaurant from people who went: review, pizza. Tap to play.

Videos by 680 The Fan · 680 The Fan, playing in the creator’s official Facebook / Instagram players.Not affiliated with DiscoverHappyHours.

Happy Hour

Updated August 2026

Zio’s Twelve 21 Pizzeria & Restaurant does not currently offer a confirmed happy hour. The restaurant features a food menu with prices across 88 verified items, available in full detail below.

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Updated August 2026

Zio's Twelve 21 Pizzeria & Restaurant

House Favorites

Cheese Pizza

Classic cheese or create your own pizza

$15.45

Twelve21 Special Pizza

Pepperoni, green peppers, onions, mushrooms, Italian sausage & sliced meatballs

$17.95

Antipasto Salad

Chopped cured meats, fresh cheeses, and briny olives. The ultimate starter

$16.95

Zio's Traditional Pizza

Cheese Pizza

Classic cheese or create your own pizza

$15.45

Stuffed Pizza

Cheesesteak Stuffed Pizza

Stuffed with steak, green peppers, onion, cheese & sauce

$22.95

Pepperoni & Sausage Stuffed Pizza

Stuffed with pepperoni, sausage, cheese & sauce

$22.95

Specialty Pizza

Twelve21 Special Pizza

Pepperoni, green peppers, onions, mushrooms, Italian sausage & sliced meatballs

$17.95

Twelve21 Veggie Special Pizza

Mushrooms, green peppers, broccoli, onions, spinach, black olives & tomatoes

$17.95

Original Sicilian Pizza

Sicilian Cheese Pizza

$23.95

Sicilian Special Pizza

$26.95

Sicilian Veggie Special Pizza

$26.95

Gourmet Pizza

Bianca Neve Pizza

Mozzarella, ricotta & parmesan cheese

$18.45

Bianca Neve Pizza with Spinach & Tomato

Mozzarella, ricotta & parmesan cheese

$20.45

Bath Avenue Pizza

Garlic, broccoli & sausage

$18.45

Court Street Pizza

Fresh mozzarella, capers & anchovies

$18.45

18th Avenue Pizza

Prosciutto, spinach & tomatoes

$18.45

Gravesend Pizza

Sausage, meatball, capicola, salami & basil

$18.45

Red Hook Pizza

Eggplant, tomato & roasted garlic

$17.45

Margherita Pizza

Fresh mozzarella, fresh basil & tomato sauce

$17.95

Primavera Pizza

Ricotta cheese, spinach, tomatoes, eggplant & garlic

$18.45

Appetizers

Fried Calamari

$16.95

Mussels

Red or white

$15.95

Chicken Wings

Italian, buffalo or BBQ

$15.95

Garlic Knots

$5.95

Garlic Bread with Cheese

$10.95

Bruschetta

Fresh tomato, olive oil, basil on garlic bread & balsamic reduction

$10.95

Salads

Garden Salad

Fresh lettuce, tomatoes, green peppers, red onions, cucumbers, and black olives

$10.95

Caesar Salad

Crisp romaine tossed with croutons, caesar dressing, and grated cheese

$12.95

Greek Salad

Tomatoes, cucumbers, onions, olives, and feta cheese in an creamy greek

$13.95

Antipasto Salad

Chopped cured meats, fresh cheeses, and briny olives. The ultimate starter

$16.95

Cobb Salad

Lettuce with tomato, bacon, grilled chicken breast, hard-boiled egg, avocado, bleu cheese, and choice of dressing

$15.95

Chef Salad

$15.95

Mozzarella Caprese Salad

Made of sliced fresh mozzarella, tomatoes, and sweet basil, seasoned with salt and olive oil

$11.95

Sides

Sauteed Spinach

$6.95

Sauteed Broccoli

$6.95

Sauteed Mushrooms

$6.95

Meatballs

$7.95

Sausage

$7.95

French Fries

$7.95

Italian Specialties

Cheese Calzone

Filled with ricotta & mozzarella

$14.95

Stromboli

Filled with ham, salami, green peppers, onions, mozarella & pizza sauce

$15.95

Toasted Heroes

Grinders. Served with choice of salad or French fries

Meatball Parm Hero

$14.45

Sausage & Peppers Parm Hero

$14.45

Chicken Parm Hero

$14.45

Eggplant Parm Hero

$13.95

Veal Parm Hero

$16.95

Italian Hot Hero

Ham, salami, capicola, provolone, banana peppers, onions, lettuce, tomato & oil/vinegar

$15.45

Italian Cold Hero

Salami, capicola, prosciutto, roasted red peppers, lettuce, tomato, banana peppers & oil/vinegar

$15.45

Philly Cheesesteak Hero

$12.45

Philly Cheesesteak Hero with Peppers & Onions

$14.45

Chicken Cheesesteak Hero

$12.45

Chicken Cheesesteak Hero with Peppers & Onions

$14.45

Wraps

Chicken Caesar Wrap

Romaine, parmesan & Caesar dressing

$13.95

Buffalo Chicken Wrap

Mixed greens, tomato, blue cheese & onion

$13.95

Turkey Bacon Avocado Wrap

Cheddar jack, lettuce, tomato & ranch

$13.95

Italian Wrap

Capicola, ham, salami, provolone, lettuce, tomato, onion & oil & vinegar

$14.95

Burgers

Basic Burger

Certified angus chuck/brisket, served on a toasted challah bun with lettuce, tomato, onion & pickles

$14.65

Build Your Own Burger

Options including applewood smoked bacon, sauteed mushrooms, grilled onions, avocado & choice of cheese

$16.65

Bruschetta Burger

Ripe tomato, olive oil, garlic, basil & fresh mozzarella with balsamic reduction

$16.65

Pizza Burger

Pizza sauce, pepperoni slices & mozzarella cheese

$16.65

Pasta

Spaghetti & Tomato Sauce

$14.95

Spaghetti & Sausage

$16.95

Spaghetti & Meatballs

$16.95

Spaghetti & Meat Sauce

$16.95

Spaghetti, Garlic & Oil

$14.95

Penne Ala Vodka

Tossed with a rich tomato & roasted garlic cream sauce & cooked vodka

$17.95

House Specialties

Fettuccine Alfredo

Fettuccini tossed in our made-toorder Alfredo sauce

$18.95

Chicken Piccata

Lightly dusted & pan-seared, finished in a white wine lemon butter sauce with capers

$21.95

Veal Piccata

Lightly dusted & pan-seared, finished in a white wine lemon butter sauce with capers

$23.95

Chicken Marsala

Lightly dusted & pan seared, finished with fresh mushrooms in a sweet Marsala sauce

$21.95

Veal Marsala

Lightly dusted & pan seared, finished with fresh mushrooms in a sweet Marsala sauce

$23.95

Gnocchi Bolognese

Potato dumplings in a rich creamy meat sauce

$18.95

Al Forno

Ziti

Ziti with mozzarella and tomato sauce baked to perfection in our oven

$16.95

Manicotti

A large tube of fresh pasta stuffed with a blend of soft cheese

$16.95

Ravioli

Ravioli filled with cheesy goodness, baked with fresh homemade sauce and mozzarella cheese

$16.95

Lasagna

Stacked layers of pasta packed with meat and cheese, covered in red sauce

$18.95

Eggplant Parmigiana

Breaded, lightly pan-seared with tomato sauce, mozzarella & parmesan

$16.95

Parmigiana

Chicken Parmigiana

Chicken cutlet breaded, lightly pan seared with tomato sauce, mozzarella & parmesan

$21.95

Veal Parmigiana

Veal cutlet breaded, pan-seared with tomato sauce, mozzarella & parmesan

$23.95

Kids Menu

Kid's Chicken Fingers

$7.00

Kid's Spaghetti & Meatballs

Spaghetti with marinara sauce and meatballs

$7.00

Kid's Macaroni & Cheese

Classic mac & cheese

$7.00

Desserts

Cannoli

$4.45

Limoncello

$4.45

MUD Pie

$4.45

Cheesecake

$4.45

Full Menu

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Photos & Gallery

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Frequently Asked Questions

What food does Zio’s Twelve 21 Pizzeria & Restaurant serve?

Zio’s Twelve 21 Pizzeria & Restaurant publishes Zio's Twelve 21 Pizzeria & Restaurant, 84 dishes. Dishes start at 5.95.

Does Zio’s Twelve 21 Pizzeria & Restaurant have dessert?

Yes, 4 on the menu. Cannoli 4.45, Limoncello 4.45, MUD Pie 4.45.

Where is Zio’s Twelve 21 Pizzeria & Restaurant located?

Zio’s Twelve 21 Pizzeria & Restaurant is located at 1221 S Sumter Blvd, North Port, FL 34287.

Is Zio’s Twelve 21 Pizzeria & Restaurant good for groups?

Zio’s Twelve 21 Pizzeria & Restaurant is a pizza restaurant in North Port. For large groups, we recommend calling ahead at (941) 426-9800 to check availability.

What type of restaurant is Zio’s Twelve 21 Pizzeria & Restaurant?

Zio’s Twelve 21 Pizzeria & Restaurant is a pizza restaurant located in North Port, FL.